Thyroid Function in Late Preterm Infants

Christiana Care Health Services

Status: Completed

Conditions: Transient Hypothyroxinemia

Study type: Observational

Funder types: Other

Identifiers

NCT00971555

CCC#29111

Details and patient eligibility

About

Transient hypothyroxinemia (TH) is a condition characterized by low levels of serum thyroxine (T4) and normal levels of thyroid stimulating hormone (TSH). TH in premature infants has been found to be related to severity of illness. T4 levels in very low birth weight infants born prematurely has been found to be inversely correlated to severity of illness. In very low birth weight infants, TH has been associated with poor outcomes. Little is known about thyroid function in late preterm infants.

Hypotheses:

1. Ill late preterm infants will have lower total T4 levels than healthy late preterm infants.
2. Total T4 and possibly TSH levels will be inversely correlated with short-term outcomes.
3. Late Preterm infants born by cesarean section will have lower T4 levels compared to those born by vaginal birth.

Enrollment: 150 estimated patients

Sex: All

Ages: Under 7 days old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• any infant born between 34 0/7 weeks and 36 6/7 weeks gestation born at Christiana Hospital

Exclusion criteria

• outborn infants
• infants with major congenital anomalies

Trial design

150 participants in 1 patient group

Late preterm

Description:

Late preterm infants admitted to the NICU