Thyroid Nodule Gene Sequencing in a Danish Population

Aarhus University Hospital

Status: Active, not recruiting

Conditions: Thyroid Nodule (Diagnosis); Thyroid Cancer

Treatments: Genetic: Molecular analyses

Study type: Interventional

Funder types: Other

Identifiers

NCT05377736

Thy-sec-da 032022

Details and patient eligibility

About

This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.

Patients with thyroid nodules suspected of malignancy is included prospectively.

Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thyroid nodule >1.5 cm
• BSRTC: IV, V, og VI

Exclusion criteria

• No surgical specimen available
• Purely cystic nodules

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Molecular testing

Experimental group

Description:

Descriptive and explorative study including identical molecular analyses applied to all included patients

Treatment:

Genetic: Molecular analyses