Tidal Irrigation Versus Intra-articular Steroid Injection in the Treatment of Knee Osteoarthritis

Portsmouth Hospitals NHS Trust

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Procedure: TI of the knee; Procedure: Intra-articular CSI

Study type: Interventional

Funder types: Other

Identifiers

NCT01303666

SEO118

Details and patient eligibility

About

Previous studies have indicated that patient expectations, beliefs and preferences may have an impact on treatment outcomes. The KIVIS study was primarily designed to compare two effective treatments for knee osteoarthritis (tidal irrigation (medical washout of the knee) or intra-articular corticosteroid injection). At study entry any preference expressed by the patient for each of the treatment interventions was recorded. This study assessed the effects of two treatments given at a single time-point and hence the effects of patient preference could be assessed independently of any compliance issues.

Enrollment: 150 patients

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of knee OA
• Knee pain for most days of the prior month
• Radiographic evidence consistent with knee OA
• Aged between 40 and 90 years old

Exclusion criteria

• Symptomatic hip OA
• Co-existent inflammatory or crystal arthritis
• Prior knee surgery
• Injury to the knee in the preceding 6 months
• Any intra-articular injection in the preceding 3 months
• Inability to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups

TI of the knee

Active Comparator group

Treatment:

Procedure: TI of the knee

Intra-articular CSI

Active Comparator group

Treatment:

Procedure: Intra-articular CSI