Tight Glycemic Control in Acute Exacerbations of COPD

Soroka University Medical Center

Status

Unknown

Conditions

Hyperglycemia

COPD

Treatments

Drug: tight insulin treatment in patients hospitalized with COPD exacerbation

Procedure: tight glycemic control

Study type

Interventional

Funder types

Other

Identifiers

NCT00452296

sor450807ctil

Details and patient eligibility

About

Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units.

Patients with acute exacerbation of COPD (AECOPD)and diabetes treated with insulin had a longer in-patient stay and more frequent isolation of Gram negative bacteria from sputum than those without diabetes.Hyperglycemia (>11 mmol/l) on admission predicted failure of non-invasive ventilation and infectious pulmonary complications in patients admitted to the ICU with acute respiratory failure caused by severe AECOPD.

The primary goal of this study is to test the hypothesis that in AECOPD, tight glycemic control during hospital stay will improve outcome of hospitalization.

The secondary goal of this study is to test new ways in controlling patients in the internal medicine ward.

Enrollment

84 estimated patients

Sex

All

Ages

45 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

current or past smokers (at least 20 py)
patient with COPD be ATS criteria
hospitalized with acute exacerbation, 2/3 criteria:1- worsening of SOB 2-change in sputum volume 3- change in sputum color
signed informed concent

Exclusion criteria