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Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Sleep Apnea
High Altitude Pulmonary Hypertension

Study type

Observational

Funder types

Other

Identifiers

NCT03165019
01-8/433

Details and patient eligibility

About

The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participated in the study in 2012 to undergo follow-up examinations in 2017, in order to allow comparisons of current results with baseline data from 2012.

Enrollment

165 patients

Sex

All

Ages

16+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
  • healthy subjects (high altitude controls)
  • Both genders
  • Age >16 y
  • Kyrgyz ethnicity
  • born, raised and currently living at >2500 m
  • healthy subjects currently living at <1000 m (low altitude controls)

Exclusion criteria

  • Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
  • Excessive erythrocytosis
  • Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
  • Regular use of medication that affects control of breathing
  • Heavy smoking

Trial design

165 participants in 3 patient groups

High altitude pulmonary hypertension
Description:
Highlanders with high altitude pulmonary hypertension living above 2500 m.
High altitude control
Description:
Healthy highlanders living above 2500 m.
Low altitude control
Description:
Healthy lowlanders living below 1000 m.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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