Time Course of Postprandial Protein Metabolism

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Protein Metabolism; Muscle Protein Synthesis

Treatments: Dietary Supplement: Milk Protein Concentrate

Study type: Interventional

Funder types: Other

Identifiers

NCT04121689

14234

Details and patient eligibility

About

The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults. Our aim was assess the time course of anabolic signaling events and stimulation of muscle protein synthesis rates (MPS) after ingestion of a food source that represents a more typical meal-induced pattern of aminoacidemia, namely milk protein concentrate, in healthy young males.

Enrollment: 7 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Males
• Aged between 18-35 years
• Healthy, recreationally active
• BMI < 30 kg/m2

Exclusion criteria

• Smoking
• Allergies to milk proteins
• Vegetarians
• Diagnosed GI tract diseases
• Female
• Arthritic conditions
• A history of neuromuscular problems
• Previous participation in amino acid tracer studies
• Predisposition to hypertrophic scarring or keloid formation
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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7 participants in 1 patient group

Milk Protein Concentrate

Experimental group

Description:

Seven young men (age: 22±1 y) will undergo repeated blood and biopsy sampling during primed continuous L-\[ring-2H5\]phenylalanine and L-\[1-13C\]leucine tracer infusions, and ingested 38 g of L-\[1-13C\]phenylalanine- and L-\[1-13C\]leucine-labeled milk protein concentrate

Treatment:

Dietary Supplement: Milk Protein Concentrate