Time Interval for Endoscopic Variceal Ligation
Status and phase
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Treatments
Details and patient eligibility
About
Patients with liver disease frequently present to the hospital with bleeding from dilated veins in their foodpipe (called esophageal varices). The current standard of care is to perform endoscopic variceal ligation (placing rubber bands around the varices through an endoscope)in patients presenting with bleeding varices. Patients generally receive ligation at the time they come in with bleeding and then return at regular intervals to have repeat ligation in order to eradicate the varices. However there have been no studies to determine the appropriate intervals for esophageal variceal ligation until eradication. We will conduct a randomized comparison of 1-week vs. 2-week intervals for esophageal ligation in patients that have presented with bleeding varices. Our hypothesis is that one-week ligation will achieve more rapid eradication than the two-week interval with a greater proportion of patients achieving variceal eradication at 4 weeks after the index bleeding episode.
Enrollment
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Volunteers
Inclusion criteria
- Patients who presented with acute upper GI bleeding due to esophageal varices and underwent successful endoscopic variceal ligation.
- Patients who would normally receive repeat endoscopic ligation therapy to eradicate varices.
Exclusion criteria
- Persistent bleeding despite endoscopic and medical therapy
- Platelet count < 40,000
Trial design
Primary purpose
Allocation
Interventional model
Masking
90 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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