Time-Restricted Eating and Bipolar Disorder

University of California (UC), Berkeley

Status

Terminated

Conditions

Bipolar Disorder

Treatments

Behavioral: time-restricted eating

Study type

Interventional

Funder types

Other

Identifiers

NCT06105294

2022-10-15725

Details and patient eligibility

About

This is a pilot trial to examine the acceptability and feasibility of time-restricted eating as an adjunct to medication treatment for bipolar disorder.

Full description

Time-restricted eating (TRE) is a way of scheduling food intake that has been shown to improve circadian rhythms in animals and humans. TRE is based on animal and human science that shows that the timing of eating powerfully influences diurnal rhythms. Animal research has shown that feeding during sleep periods leads to a surge of norepinephrine, cortisol, wakefulness, and activity. Drawing on this, over a decade of studies have examined the impact of experimentally randomizing mice to time-restricted feeding during wake hours (vs. 24-hour ad libitum feeding). Importantly, caloric intake and other facets of diet were yoked for strict control. A consistent finding is that TRE had powerful benefits for circadian and metabolic indicators across studies,and more recent data also shows benefit for animal longevity.

Here, the investigators' goal is to extend this work to bipolar disorder (BD). More specifically, the investigators will gather data to examine the acceptability and feasibility of TRE among those who self-identify with bipolar disorder and who experience some problems with sleep, circadian rhythms, or schedules. The investigators will gather measures of mania, depression, sleep, and QOL, to provide preliminary evidence of change on these dimensions.

Enrollment

1 patient

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

adults diagnosed with bipolar disorder and currently receiving medical care for their bipolar disorder.
Experiencing schedule/sleep or circadian problem in the past 3 months
Medication regimens stable for past month
Adequate English language skills for taking part in the program.
Living in California.

Exclusion criteria

Cognitive deficits (Screening OMC Test)
Current: psychosis, (hypo)mania, major depressive episode, substance/alcohol use disorders, eating disorder diagnoses or acute suicidal risk (MINI interview; see DSM5 TRE screening)
High scores (> 5) on the Screening Eating Disorder Examination Questionnaire
Current shift work
>5 kg weight change within 3 months
Pregnancy
Breastfeeding
Uncorrected hypo or hyperthyroidism

* diabetes type 1
Gastrointestinal conditions impairing nutrient absorption
Medications contraindicated for fasting, including clozapine, glucose-lowering medications, diabetes-related injections, requiring food early morning or late evening, corticosteroids.