Time-restricted Eating in Survivors Trial (TEST)

University of Alberta

Status: Completed

Conditions: Cancer, Breast

Treatments: Behavioral: Time-restricted eating

Study type: Interventional

Funder types: Other

Identifiers

NCT05639829

HREBA.CC-20-0077

Details and patient eligibility

About

Breast cancer survivors aged 60+ and with overweight/obesity who had completed chemotherapy 1-6 years earlier completed 8 weeks of 12-8 pm weekday-only time-restricted eating. The intervention was delivered by a registered dietitian call, twice-daily automated text messages asking about eating start/stop times, and three support phone calls.

Enrollment: 22 patients

Sex: Female

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• history of early-stage (I-III) breast cancer
• completed anthracycline-based chemotherapy 1-6 years earlier
• aged ≥60 years
• had a body mass index (BMI) >25 kg/m2

Exclusion criteria

• taking lipid, glucose, or weight-lowering medications
• contraindications to maximal exercise testing or research MRI
• unstable thyroid disorder
• self-reported history of an eating disorder
• self-reported diagnosis of type 1 or 2 diabetes
• weight loss of ≥15 lbs in previous 3 months
• working night shifts
• could not provide consent in English

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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22 participants in 1 patient group

Weekday time-restricted eating

Experimental group

Description:

The intervention consisted of 8 weeks of ad libitum TRE with a 12-8 pm 8-hour eating window on weekdays. Participants received instructions to only consume water, black coffee, or black tea from 8 pm to 12 pm on weekdays and during the weekend, where there were no restrictions on eating timing. No other dietary or physical activity instructions were given.

Treatment:

Behavioral: Time-restricted eating