Timing and Intrauterine Insemination in Unexplained Infertility

Sohag University

Status and phase: Unknown; Phase 4

Conditions: Intrauterine Insemination

Treatments: Drug: hCG

Study type: Interventional

Funder types: Other

Identifiers

NCT03920514

Intrauterine insemination

Details and patient eligibility

About

to determine the most suitable time for administration of (human chorionic gonadotropin )hCG prior to intrauterine insemination (IUI) to optimize pregnancy outcome and to have the best success rates so the cases divided in to four groups according to the time of hCG administration .

Full description

IUI with or without ovarian stimulation is a common treatment for infertility ,it is a simple procedure the semen is prepared in the laboratory and transferred by a catheter and injected intrauterine .ultrasound folliculometry is used for monitoring follicular growth where some clinicians prefer the natural cycles and others prefer ovarian stimulation and human chorionic gonadotropin (hCG)trigger for better timing .so cases will take induction and folliculometry will be done until the follicle reach 18mm trigger with hCG .women will be randomly divided to four groups .the first group will undergo IUI at 24 after trigger the second IUI at36 hour after trigger the thirdG at 48 after trigger and finaly the last group IUI will be done simultaneos with trigger the out come the number of pregnant women for each group.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild male infertility or unexplained infertility

Exclusion criteria

• Adanced male factor endometriosis uterine abnormality sever semen parameters i impairment according to WHO 2010 non ovulatory cycles bilatral tubal block

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 4 patient groups

GROUP 1

Active Comparator group

Description:

IUI 24 hours after hCGadminstration

Treatment:

Drug: hCG

GROUP 2

Active Comparator group

Description:

IUI 36 hours after hCG adminstration

Treatment:

Drug: hCG

GROUP 3

Active Comparator group

Description:

IUI 48 hours after hCG adminstration

Treatment:

Drug: hCG

GROUP 4

Active Comparator group

Description:

IUI at time of hCG adminstration

Treatment:

Drug: hCG