Timing of COC Denudation and Embryo Quality

Acıbadem Atunizade Hospital

Status: Unknown

Conditions: Infertility, Female

Treatments: Other: early denudation; Other: late denudation

Study type: Observational

Funder types: Other

Identifiers

NCT03813745

COCdenudation

Details and patient eligibility

About

The relation between the timing of COC denudation and oocyte /embryo quality is controversial. The aim of this study is to examine whether timing of denudation of sibling oocytes has any effect on embryo quality.

Full description

Retrieved sibling cumulus-oocyte complexes (COCs) will be randomly divided into two groups, in the first group denudation will be in 30 minutes after oocyte retrieval, in second group denudation will take place after 2 hours of incubation.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COH with GnRH antagonist cycle
• 5 or more oocytes collected

Exclusion criteria

• Fewer than 4 oocytes after retrieval
• Previous history of total fertilization failure or oocyte maturation arrest
• Male partner requiring surgical sperm retrieval (MESA or TESA).

Trial design

100 participants in 2 patient groups

early denudation

Description:

Cumulus-oocyte complexes will be denudated in 30 min after oocyte retrieval

Treatment:

Other: early denudation

late denudation

Description:

Denudation will be done 2 hr after oocyte retrieval

Treatment:

Other: late denudation