Timing of Intrauterine Insemination (IUI) 24 or 48 Hours After Spontaneous Luteinizing Hormone (LH) Peak

Universitair Ziekenhuis Brussel

Status and phase: Completed; Phase 4

Conditions: Pregnancy

Treatments: Procedure: intra-uterine insemination

Study type: Interventional

Funder types: Other

Identifiers

NCT01622023

1/2012

Details and patient eligibility

About

The aim of the present study is to prospectively evaluate whether performing an intra-uterine insemination 24 hours after the spontaneous LH peak may result in significantly higher ongoing pregnancy rates compared to 48 hours.

Enrollment: 435 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• below 39 years of age on the day of LH peak
• donor semen
• natural cycle (without CC)
• cycle with less than 3 follicles reaching 15 mm of diameter or more.
• with basal hormonal values of progesterone ( < 1,2 ng/dl)

Exclusion criteria

The patients excluded are women

• who underwent more than 6 intrauterine inseminations,
• with tubal infertility

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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435 participants in 2 patient groups

Study group

Experimental group

Description:

intrauterine insemination after 24 hours

Treatment:

Procedure: intra-uterine insemination

Control group

Active Comparator group

Description:

intrauterine insemination after 48 hours

Treatment:

Procedure: intra-uterine insemination