Timing of Resistance Exercise in Type 1 Diabetes (T-REX)

Dasman Diabetes Institute

Status: Enrolling

Conditions: Type 1 Diabetes

Treatments: Behavioral: Morning exercise; Behavioral: Habitual physical activity levels; Behavioral: Afternoon exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05884814

RA HM-2023-009

Details and patient eligibility

About

The aims of the current study are

1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.
2. to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes

Enrollment: 54 estimated patients

Sex: All

Ages: 21 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Physician confirmed type 1 diabetes for at least 1 year
• Stable insulin therapy for 3 months prior to the study

Exclusion criteria

• BMI of 45 or higher
• BP of 160/100mmHg or higher
• autonomic neuropathy
• severe proliferative retinopathy
• joint or limb injuries preventing weight-bearing activity
• autonomic neuropathy
• severe proliferative retinopathy
• any other medical condition that prevents participants from exercising safely.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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54 participants in 3 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Habitual physical activity

Treatment:

Behavioral: Habitual physical activity levels

Morning exercise

Active Comparator group

Description:

Exercise training between 6-10am

Treatment:

Behavioral: Morning exercise

Afternoon exercise

Active Comparator group

Description:

Exercise training between 4-8pm

Treatment:

Behavioral: Afternoon exercise