Timolol Eye Drops in the Treatment of Acute Migraine Headache

University of Missouri, Kansas City

Status: Terminated

Conditions: Migraine

Treatments: Drug: Artificial tears; Drug: Timolol eye drops

Study type: Interventional

Funder types: Other

Identifiers

NCT02630719

#15-060 (Other Identifier)

15-152

Details and patient eligibility

About

The goal of this study is to determine whether timolol eye drops are effective in alleviating acute migraine headaches. Subjects will be randomized to receive either timolol eye drops or placebo (tears) to use as a migraine abortive medication.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of migraine headache

Exclusion Criteria

• Non-migraine headache
• Use of systemic beta-blocker
• Medical history of hypotension, bradycardia, syncope or other significant cardiovascular disease
• Medical history of difficulty breathing, asthma or chronic obstructive pulmonary disease or other pulmonary disease
• Medical history of glaucoma, ocular hypertension or hypotony, punctual stenosis, current use of other ophthalmic medications
• Previous adverse reaction to timolol or other beta-blockers
• Inability to self-administer eye drop due to physical or cognitive disorders
• Currently pregnant or breastfeeding
• Pregnant in the past year
• Non-english speaker

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups, including a placebo group

Timolol eye drops

Active Comparator group

Description:

All subjects received timolol eye drops or placebo (artificial tears) for two months then crossed over to the opposite medication for the final two months of the study.

Treatment:

Drug: Timolol eye drops

Artificial tears

Placebo Comparator group

Description:

All subjects received timolol eye drops or placebo (artificial tears) for two months then crossed over to the opposite medication for the final two months of the study.

Treatment:

Drug: Artificial tears