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Rationale: Individuals with advanced age are at a progressively increasing risk of acquiring lower respiratory tract infections. Besides calendar age, the degree of frailty also associates with increased susceptibility to pneumonia requiring hospitalization. How alterations in the mucosal immune system with advanced age predispose to infections remains unclear as access to relevant tissue samples is limited. With minimally-invasive nasal sampling methods, it was recently observed that in vital older adults, both CD4+ T cells and CD8+ T cells are selectively lost from the nasal mucosa. However, the exact phenotype, underlying mechanisms, key molecules and consequences of this have not yet been investigated.
Objective:
Elucidate the mechanisms underlying the loss of nasal T cells and characterize in depth the differences of T cells in young and older adults and associate this loss with susceptibility to infections.
Study design: Prospective cohort study
Study population: Participants will be recruited from 3 groups:
Main study parameters/endpoints: Frequency of nasal CD8+ T cells in young adults and frail older adults.
Secondary study parameters/endpoints:
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Inclusion criteria
•Adults able and willing to provide informed consent.
Specific inclusion criteria per group:
Exclusion criteria
170 participants in 3 patient groups
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Central trial contact
Simon P Jochems, PhD
Data sourced from clinicaltrials.gov
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