Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema

Gelb, Arthur F., M.D.

Status: Completed

Conditions: Emphysema; COPD

Treatments: Drug: tiotropium

Study type: Observational

Funder types: Industry

Identifiers

NCT00570544

1000

Boehringer-Ingelheim Pharm.

Pfizer

Details and patient eligibility

About

To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by high resolution-thin section CT lung.

Full description

We will analyze post hoc, data that was previously published: Gelb AF et al.Chest 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity thereby providing lung volume protection against metronome paced hyperventilation induced dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic hyperinflation with extent of lung CT scored emphysema.

Enrollment: 29 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• moderate to severe copd

Exclusion Criteria

• unable to tolerate tiotropium
• unable to perform metronome paced hyperventilation induced dynamic hyperinflation

Trial design

29 participants in 1 patient group

1

Description:

patients with moderate to severe copd with varying extent of emphysema

Treatment:

Drug: tiotropium