Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients

Mount Sinai Health System

Status: Completed

Conditions: Polycythemia Vera; Essential Thrombocythemia

Treatments: Procedure: Blood specimen

Study type: Observational

Funder types: Other

Identifiers

NCT01970930

GCO 12-0481

Details and patient eligibility

About

The purpose of the study is to isolate and characterize stem cells of patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) to find out why these cells are not working the way they should be and why they seem to be sensitive to regulatory factors in the blood, such as clotting.

Full description

Specific Aim 1: Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.

Specific Aim 2. Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC.

Enrollment: 131 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• polycythemia vera or essential thrombocythemia
• agree to give blood for study

Exclusion criteria

• none

Trial design

131 participants in 1 patient group

PV or ET

Description:

subject who has polycythemia vera or essential thrombocythemia

Treatment:

Procedure: Blood specimen