Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)

Hospital Clinic of Barcelona

Status and phase: Completed; Phase 3

Conditions: Cardiac Resynchronization Therapy; Heart Failure

Treatments: Device: Electrocardiographic optimization of the interventricular pacing delay according to QRS width; Device: Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves

Study type: Interventional

Funder types: Other

Identifiers

NCT01179997

CRT-opt

Details and patient eligibility

About

The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width criteria.

Enrollment: 156 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients submitted to de novo implant due to conventional cardiac resynchronization therapy indications.

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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156 participants in 2 patient groups

Tissue Doppler Imaging (TDI) optimization

Active Comparator group

Description:

Interventricular pacing delay optimized according to Tissue-Doppler echocardiography

Treatment:

Device: Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves

Electrocardiographic optimization

Active Comparator group

Description:

Interventricular pacing delay optimized according to QRS width observation in the 12-lead surface electrocardiogram

Treatment:

Device: Electrocardiographic optimization of the interventricular pacing delay according to QRS width