Tissue Inhibitor of Metalloproteinases 2 Level in Patients Undergoing Cardiac Surgery

Wuhan University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Surgery; Acute Kidney Injury; Extracorporeal Circulation; Complications

Treatments: Drug: TIMP2 level

Study type: Interventional

Funder types: Other

Identifiers

NCT06871826

202123306

Details and patient eligibility

About

Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP2) is associated with ischemia-reperfusion injury. In this study, relationship between TIMP2 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of TIMP2 for early prediction of CSA-AKI was further evaluated.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients (≥18 years old) underwent on-pump cardiac surgery
• admitted to ICU immediately after surgery

Exclusion criteria

• Patients younger than 18 years
• with prior AKI
• end-stage kidney disease
• need for chronic hemodialysis
• pregnant patients
• unable to give written consent for participation

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 3 patient groups

TIMP2 Tertile 1

Experimental group

Description:

Other: TIMP2 level

Treatment:

Drug: TIMP2 level

TIMP2 Tertile 2

Experimental group

Description:

Other: TIMP2 level

Treatment:

Drug: TIMP2 level

TIMP2 Tertile 3

Experimental group

Description:

Other: TIMP2 level

Treatment:

Drug: TIMP2 level