Tissue Kallikrein Protect Against Ischemic Stroke

Qin Zhang

Status: Completed

Conditions: Stroke, Ischemic

Treatments: Other: No Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06422572

TJ-IRB202303109

Details and patient eligibility

About

The results of previous studies were used to assess the causal association between TK levels and stroke occurrence at 5 and 12 years of follow-up, respectively.

Full description

Analyze the data of a 5-year follow-up on 2115 control individuals from the case-control study of the previous research. We completed the 5-year follow-up on this group in 2016 (whether they had a stroke, whether they are alive, and the cause of death).

Conduct a 12-year follow-up on 6487 community individuals from the previous study (whether they had a stroke within 12 years, whether they are alive, and the cause of death). We collaborated with the hospital platform's computer center to conduct follow-up through AI questionnaire surveys, followed by supplementing AI questionnaire data with telephone questionnaire surveys for those lost to follow-up.

Utilize R language R Studio 4.11 for statistical analysis and plotting. Evaluate the distribution of TK levels in the control group and its relationship with the 10-year predicted risk of stroke and the predictive role for stroke events within 5 years.

Evaluate the distribution of TK levels in the community group and its relationship with the 10-year predicted risk of stroke and the predictive role for stroke events within 12 years.

Enrollment: 8,602 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Control population in the previous stroke case-control study;
• 2. The CHD case-control population in the previous study;
• 3. The population in the community cross-sectional study of the previous study.

Exclusion criteria

• Stroke patient

Trial design

8,602 participants in 1 patient group

Population without stroke

Description:

1. Control population in a case-controlled study of prior stroke ; 2. Control population in a case-controlled study of preexisting coronary heart disease; 3. Population in previous community cross-sectional studies .

Treatment:

Other: No Intervention