Tissue Lesions in Exercise Related Ischemia (SARTORIUS)

University Hospital, Angers

Status: Completed

Conditions: Peripheral Artery Disease; Ischemia

Treatments: Other: Muscle Biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT02834351

2013-A00166-39

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of muscle ischemia during claudication on mitochondrial function.

Comparison to patients with arterial disease but absence of lower limb claudication (Cardiac group) feasibility study.

Full description

Assess the feasibility of the study of micro-vascular function and mitochondrial on muscle sample (sartorius) in a group of arterial disease and non arteriopathy group.

Analysis of the activity of mitochondrial chain Immunochemistry of tissue markers

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intervention for femoropopliteal bypass (PAD group)
• Intervention for saphenous withdrawal for coronary bypass surgery (cardiac group)

Exclusion criteria

• Participate in another biomedical research
• Pregnant woman

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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36 participants in 2 patient groups

Peripheral artery diseased group

Active Comparator group

Description:

pad Patients referred for femoro popliteal bypass Muscle biopsy during surgery

Treatment:

Other: Muscle Biopsy

Cardiac group

Sham Comparator group

Description:

Patients referred for saphenous withdrawal for coronary bypass Muscle biopsy during surgery

Treatment:

Other: Muscle Biopsy