Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Liaquat National Hospital & Medical College

Status and phase: Completed; Phase 1

Conditions: Dental Plaque

Treatments: Drug: Chlorhexidine mouthwash; Other: Natural honey

Study type: Interventional

Funder types: Other

Identifiers

NCT05258955

1030419MAOM

Details and patient eligibility

About

The rationale of our study is to compare the efficacy of natural honey base preparation with other commercially available mouthwashes i.e chlorhexidine base in prevention of dental plaque formation as honey is readily available and cost effective and organic in nature. This study will help to provide the data of our community and positive result may provide a new method of oral hygiene maintenance with fewer side effects. We will be able to deliver the best anti-plaque agent.

Full description

In this study, participants will assigned into 2 group those who will fulfilled the inclusion and exclusion criteria. After the informed consent, they were divided into 2 group. Group A will received Chlorhexidine mouthwash and Group B will provided with honey based mouthwash. The participant will blinded as solution will be provided in dark color bottle to mask the study. After which the baseline plaque index will be taken followed by recording plaque index on 7th, 14th, and 21st day. The statistical analysis will be done to compare the mean difference between these 2 groups

Enrollment: 60 patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Individual aged between 18-25
2. Retained 28 number of teeth excluding wisdom teeth

Exclusion criteria

1. Individual with medical illness affecting oral cavity like diabetes, sjögren syndrome, crohn disease etc
2. Multiple extraction , overhang restoration, wearing any appliance
3. Periodontal problem with pocket depth more than 3mm
4. Current or recent history of antibiotic consumption
5. Noncompliance that is unable to maintain their hygiene.
6. Pan, Betel quid and any other oral habit will not be included in study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Chlorhexidine

Active Comparator group

Description:

these are the group which received chlorhexidine based preparation for plaque reduction

Treatment:

Drug: Chlorhexidine mouthwash

Natural honey

Experimental group

Description:

these group will received the honey base mouthwash and the its effect on plaque reduction will be observed in follow up visits

Treatment:

Other: Natural honey