TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery (TIVABAL-CRC)

Grigore T. Popa University of Medicine and Pharmacy

Status: Enrolling

Conditions: Colorectal Cancer (CRC); Sarcopenia

Treatments: Procedure: total intravenous anaesthesia; Procedure: sevoflurane anaesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT07237438

358/11.08.2025

Details and patient eligibility

About

This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer. The investigators will asess the impact of the type of anaesthesia (total intravenous anaesthesia/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass, which will be evaluated using ultrasound, dynamometry and bioimpedance.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania

Exclusion criteria

• lack the capacity to consent
• extremity amputation
• paraplegia
• diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy)
• terminal cancer

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

total intravenous anaesthesia

Active Comparator group

Treatment:

Procedure: total intravenous anaesthesia

sevoflurane anaesthesia

Active Comparator group

Treatment:

Procedure: sevoflurane anaesthesia