TLR-9 Antagonism in Steroid Resistant Optic Neuritis

Sudhalkar Eye Hospital

Status: Completed

Conditions: Optic Neuritis

Treatments: Drug: Mycobacterium w.(Mw)-freeze dried extract 0.5ml

Study type: Interventional

Funder types: Other

Identifiers

NCT01424735

21234EH

Details and patient eligibility

About

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Unilateral Steroid Resistant Optic Neuritis

Exclusion criteria

• bilateral optic neuritis
• Associated Systemic disease
• Prior treatment received

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Mw.

Experimental group

Description:

Administration of immunomodulator Mw.

Treatment:

Drug: Mycobacterium w.(Mw)-freeze dried extract 0.5ml