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TMAO and Atherosclerosis in HIV

Albert Einstein College of Medicine logo

Albert Einstein College of Medicine

Status

Completed

Conditions

Carotid Artery Plaque

Treatments

Other: No intervention

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT03416257
K01HL129892 (U.S. NIH Grant/Contract)
2015-5145

Details and patient eligibility

About

In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).

Enrollment

737 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • participants who underwent carotid artery imaging for plaque assessment at a baseline visit (2004-2006) and at a follow-up visit (2011-2013).

Exclusion criteria

  • a history of coronary heart disease, individuals with prevalent diabetes or prevalent carotid artery plaques at baseline

Trial design

737 participants in 2 patient groups

WIHS
Description:
Women's Interagency HIV Study
Treatment:
Other: No intervention
MACS
Description:
Multicenter AIDS Cohort Study
Treatment:
Other: No intervention

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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