TMS-EEG for Cortical Excitability

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Mayo Clinic

Status

Enrolling

Conditions

Healthy
Traumatic Brain Injury
Stroke
Acquired Brain Injury

Treatments

Procedure: Transcranial Magnetic Stimulation
Diagnostic Test: Electroencephalogram
Procedure: Transcranial Direct Current Stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT05472363
21-012185

Details and patient eligibility

About

This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational devices repetitive TMS or transcranial direct current stimulation (tDCS).

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria - Stroke:

- Acquired brain injury such as ischemic or hemorrhagic stroke or traumatic brain injury.

Inclusion Criteria - Healthy Controls:

- No known active neurological disorder.

Exclusion Criteria - Stroke:

  • Pregnancy
  • Contraindication to MRI or TMS including metallic implanted objects.
  • Medical instability or inability to cooperate during the study as assessed by the treating physician to participate in the study.
  • Severe aphasia.
  • History of epilepsy.
  • History of active depression or treatment resistant depression.
  • History of schizophrenia.

Exclusion Criteria - Healthy Controls:

  • Pregnancy
  • Contraindication to MRI or TMS including metallic implanted objects.
  • History of acquired brain injury.

Trial design

Primary purpose

Supportive Care

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Non-Stroke Subjects
Experimental group
Description:
Subjects will receive up to 30 minutes of focal simulation with either TMS or tDCS administered to one brain location within standard safety protocols
Treatment:
Procedure: Transcranial Direct Current Stimulation
Diagnostic Test: Electroencephalogram
Procedure: Transcranial Magnetic Stimulation
Stroke Subjects
Experimental group
Description:
Subjects will receive up to 30 minutes of focal stimulation with either TMS or tDCS administered to one brain location within standard safety protocols
Treatment:
Procedure: Transcranial Direct Current Stimulation
Diagnostic Test: Electroencephalogram
Procedure: Transcranial Magnetic Stimulation

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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