TMS-EEG for Cortical Excitability

Mayo Clinic

Status: Withdrawn

Conditions: Healthy; Traumatic Brain Injury; Stroke; Acquired Brain Injury

Treatments: Procedure: Transcranial Magnetic Stimulation; Diagnostic Test: Electroencephalogram; Procedure: Transcranial Direct Current Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05472363

21-012185

Details and patient eligibility

About

This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational devices repetitive TMS or transcranial direct current stimulation (tDCS).

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria - Stroke:

• Acquired brain injury such as ischemic or hemorrhagic stroke or traumatic brain injury.

Inclusion Criteria - Healthy Controls:

• No known active neurological disorder.

Exclusion Criteria - Stroke:

• Pregnancy
• Contraindication to MRI or TMS including metallic implanted objects.
• Medical instability or inability to cooperate during the study as assessed by the treating physician to participate in the study.
• Severe aphasia.
• History of epilepsy.
• History of active depression or treatment resistant depression.
• History of schizophrenia.

Exclusion Criteria - Healthy Controls:

• Pregnancy
• Contraindication to MRI or TMS including metallic implanted objects.
• History of acquired brain injury.

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Non-Stroke Subjects

Experimental group

Description:

Subjects will receive up to 30 minutes of focal simulation with either TMS or tDCS administered to one brain location within standard safety protocols

Treatment:

Procedure: Transcranial Direct Current Stimulation

Diagnostic Test: Electroencephalogram

Procedure: Transcranial Magnetic Stimulation

Stroke Subjects

Experimental group

Description:

Subjects will receive up to 30 minutes of focal stimulation with either TMS or tDCS administered to one brain location within standard safety protocols

Treatment:

Procedure: Transcranial Direct Current Stimulation

Diagnostic Test: Electroencephalogram

Procedure: Transcranial Magnetic Stimulation