TMS Modulation of Insula-related Brain Networks.02 (TMSINS02)

Duke University

Status

Completed

Conditions

Healthy Subjects

Treatments

Device: transcranial magnetic stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT02919423

Pro00077293

Details and patient eligibility

About

The purpose of this study is to investigate the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) on functional connectivity with the insula. Functional connectivity (FC) measures the interaction between brain regions, and recent neuroimaging studies have used FC to investigate how addiction affects FC among pertinent brain regions. rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain connectivity and could be used therapeutically to treat addiction. However, investigators first need more information on brain FC and how it relates to behavior, in order to guide rTMS target selection.

Enrollment

36 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

generally healthy
between the ages of 18-55
right-handed

Exclusion criteria

significant health problems (e.g., current and uncontrolled liver, lung, or heart problems) or presence of medical illness likely to alter brain morphology (including history of seizure, history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, and known structural brain lesion)
current diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder, schizophrenia)
meet DSM-5 criteria for current substance use disorder other than nicotine
use of psychoactive medications that would result in a positive urine drug screen
Current use of medications known to lower the seizure threshold
positive breath alcohol concentration
presence of conditions that would make MRI unsafe (e.g., metal implants, pacemakers)
among women, a positive urine pregnancy test
vision that cannot be corrected to 20/40