To Assess the Effect of HDF Versus High Flux Dialysis on Free Light Chains and Cumulative Albumin Loss, in End Stage Renal Disease Patients.

Ain Shams University

Status: Completed

Conditions: Hemodialysis; End Stage Renal Disease; Hemodiafiltration

Treatments: Device: BIOPURE 260HF dialyzer

Study type: Interventional

Funder types: Other

Identifiers

NCT04747067

HD vs HDF

Details and patient eligibility

About

Removal of uremic toxins is the main goal of HD, It was improved by using high volume convective technique with high flux (HF) dialyzer. This technique removes medium - large molecular weight solutes giving higher dialysis adequacy and consequently improving the quality of life.

This study will assess the effect of hemodiafiltration (HDF) versus high flux dialysis on free light chains (FLC) reduction as a marker of HD adequacy and its relation to albumin loss using dialyzer effective surface area 2.6m2.

Enrollment: 25 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Prevalent HD patients on regular hemodialysis sessions for >6 months 3 sessions/week of 4 hours duration.
• Patients with Arterio-venous fistula as dialysis access.

Exclusion criteria

• Patients with hemodialysis catheters.
• Patients with active inflammation or infection.
• Decompensated heart failure.
• Liver Cell Failure ( Child B,C)
• Patients with known malignancies.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

25 participants in 2 patient groups

High-flux Hemodialysis

Experimental group

Description:

patients treated by conventional hemodialysis

Treatment:

Device: BIOPURE 260HF dialyzer

Hemodiafiltration

Experimental group

Description:

patients treated by online post-dilution hemodialysis

Treatment:

Device: BIOPURE 260HF dialyzer