To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock

Institute of Liver and Biliary Sciences, India

Status

Completed

Conditions

Cirrhosis With Septic Shock

Treatments

Drug: Noradrenaline

Drug: Low dose terlipressin

Study type

Interventional

Funder types

Other

Identifiers

NCT02468063

ILBS-Cirrhosis-001

Details and patient eligibility

About

The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level study. The investigators will strictly follow the randomization table to give therapy as per the intervention arm.

Intervention:-the therapeutic intervention is vasopressor i.e. noradrenaline alone and terlipressin along with noradrenaline to maintain the MAP >65mm Hg.
Intervention arm
- Arm (A) - Noradrenaline
- Arm (B) - Noradrenaline + low dose terlipressin

Enrollment

184 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18-70 yr
Cirrhosis with septic shock not responding to fluid resuscitation within 2 hrs.

Exclusion criteria

ECG (ElectroCardiography)changes at presentation which exclude the use of vasopressin analouges
Cardiac dysfunction ( valvular heart disease, coronary artery disease)
Acute mesenteric ischemia (confirmed or suspected) or vasospastic diathesis (e.g. Reynaud's syndrome or related diseases).
Pregnancy
Acute GI bleed
No Consent