To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT (CINOECT)

Yu Danqing

Status: Unknown

Conditions: CIN

Treatments: Procedure: enhanced computed tomography

Study type: Interventional

Funder types: Other

Identifiers

NCT03872739

201704020124

Details and patient eligibility

About

To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography.

Full description

The prospective multicenter randomized controlled clinical research discusses the comparison of oral and intravenous hydration for prevention of contrast-induced nephropathy in elderly patients with enhanced computed tomography, establishing a simple hydration proposal.

Enrollment: 1,368 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age>21
• informed consent
• Undergoing Intravenous Contrast-enhanced Computed Tomography

Exclusion criteria

• CT enhancement was not performed;
• Dialysis treatment of patients with end-stage renal failure or heart, kidney transplantation;
• Exposure to radioactive contrast medium within 48 hours prior to or within 72 hours of examination;
• Acute decompensated heart failure;
• Allergic to radioactive contrast agent;
• Be subjected to life - threatening trauma;
• Severe infection;
• Surgery was performed within 2 days of CT examination.
• Combined with multiple myeloma, urinary obstruction, aortic dissection
• Can cause acute kidney injury disease;
• Use of aminoglycosides and other nephrotoxic drugs 2 weeks before.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,368 participants in 2 patient groups, including a placebo group

distilled water

Experimental group

Description:

Oral distilled water at the rate of 3 mL/kg/h rate during undergoing enhanced computed tomography examination before 1-2 and after 4-6 hours

Treatment:

Procedure: enhanced computed tomography

Saline

Placebo Comparator group

Description:

intravenous saline hydration at the rate of 1 mL/kg/h rate during undergoing enhanced computed tomography examination before and after 12 hours

Treatment:

Procedure: enhanced computed tomography