To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 3

Conditions: Chorioretinitis

Treatments: Drug: Clindamycin+Dexamethasone; Drug: pyrimethamine-sulfadiazine + prednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT00372294

8415

Details and patient eligibility

About

Toxoplasmosis, an intra cellular parasite, is a very important cause of chorioretinitis. The goal of treatment is arresting multiplication of the parasite in its inflammatory active phase. In this study the investigators try to compare the efficacy of the classic regimen (Pyrimethamine-Sulfadiazine + Prednisolon) with intravitreal Clindamycin & Dexamethasone.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Toxoplasmic chorioretinitis
• Location of the lesion within zone I of the retina or a lesion greater than 2DD with 3+-4+ vitreous inflammation in zone II or III
• No allergic history to the used drugs
• No any other diseases

Exclusion criteria

• Any allergic reaction to the used medications
• One eyed patients
• Partially treated patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

1

Active Comparator group

Description:

Classic regimen (Pyrimethamine-Sulfadiazine + Prednisolon)

Treatment:

Drug: pyrimethamine-sulfadiazine + prednisolone

2

Active Comparator group

Description:

Intravitreal Clindamycin \& Dexamethasone

Treatment:

Drug: Clindamycin+Dexamethasone