To Compare the Effect of Different Nutritional Pathways on Improving Nutritional Status of Esophageal Cancer Patients Undergoing Chemoradiotherapy

Tianjin Medical University

Status

Completed

Conditions

Enteral Nutrition

Chemoradiotherapy

Esophageal Squamous Cell Carcinoma

Treatments

Dietary Supplement: Dietary guidance

Study type

Observational

Funder types

Other

Identifiers

NCT04199832

20190920

Details and patient eligibility

About

This study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (NG), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during chemoradiation therapy (CRT).

Enrollment

156 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Pathologically or cytologically proven esophageal squamous cell carcinoma
Karnofsky performance score(KPS) ≧70
Concurrent chemoradiotherapy
Hemoglobin≥90.0g/dL,white blood cell count（WBC）≥ 4000 cells/mm³,Platelet count≥100,000 cells/mm³
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 times upper limit of normal,bilirubin normal
Creatinine normal OR creatinine clearance ≥ 60 mL/min
Patients have good compliance to treatment and follow-up of acceptance
the functions of the heart, kidney, liver were basically normal, with no chemotherapy and radiotherapy contraindications

Exclusion criteria

Patients with severely bowel function impaired or can not tolerate enteral nutrition
Patients with serious gastrointestinal obstruction, be unable to take food by mouth and can not / do not want to a feeding tube inserted
Patients who have severe vomiting, gastrointestinal bleeding, intestinal obstruction
Patients who have distant metastasis
The primary tumor or lymph node already received surgical treatment efuse or incapable to sign the informed consent form of participating this trial