To Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome

Institute of Liver and Biliary Sciences, India

Status: Withdrawn

Conditions: Hepatorenal Syndrome

Treatments: Drug: nor adrenaline and terlipressin; Drug: step up terlipressin therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01649037

ILBS-AKI-01

Details and patient eligibility

About

All consecutive patients with liver cirrhosis having Acute Kidney Injury at admission or during hospitalization will be included in the study.

The diagnosis of liver cirrhosis will be based on the clinical grounds including Laboratory tests, endoscopic evidence, imaging (Ultrasonography/computed tomography) findings, and liver histology, when available.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Liver cirrhosis and acute kidney injury. Patients consented for the study protocol by signing the informed consent.

Exclusion criteria

• Age less than 18 years Cirrhotics with kidney injury managed as outpatients. Patients undergoing renal replacement therapy (hemodialysis/renal transplantation).

Post liver transplantation patients. Hepatocellular carcinoma. History of coronary artery disease, ischaemic cardiomyopathy, ventricular arrhythmia, or peripheral vascular disease.

Patients with obstructive uropathy. Patient who withdrew or non complaint to the study protocol.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

nor adrenaline and terlipressin

Experimental group

Treatment:

Drug: nor adrenaline and terlipressin

step up terlipressin

Active Comparator group

Treatment:

Drug: step up terlipressin therapy