To Compare Therapeutic Effect of Intravitreal Bevacizumab and Triamcinolone in Resistant Uveitic Cystoid Macular Edema

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 1

Conditions: Resistant Cystoid Macular Edema

Treatments: Drug: Intravitreal injection of Triamcinolone; Drug: Intravitreal injection of Avastin

Study type: Interventional

Funder types: Other

Identifiers

NCT00371111

8524

Details and patient eligibility

About

Cystoid macular edema (CME) is one of the common causes of vision loss in patients with UveitiS .Triamcinolone has been effectively used in reducing CME and improving the vision. Also there are some documents which recommend Bevacizumab(avastin) could reduce macular edema. This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.

Full description

This study compare intravitreous injection of triamcinolone and avastin in patients with resistant uveitic cystoid macular edema.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Uveitic CME
• Uveitic CME refractory to routine treatment
• Vision better than 5/200 and worse than 20/50

Exclusion criteria

• Mono- Ocular patients
• History of vitrectomy
• Glaucoma or ocular hypertension
• History of other retinal disease that can cause macular edema
• Pregnancy
• Significant media opacity
• Vision better than 20/50

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

1

Active Comparator group

Description:

Intravitreal injection of Triamcinolone

Treatment:

Drug: Intravitreal injection of Triamcinolone

2

Active Comparator group

Description:

Intravitreal injection of Avastin

Treatment:

Drug: Intravitreal injection of Avastin