To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure (IRUSESOM0428)

Southern Arizona VA Health Care System

Status: Completed

Conditions: Gastroesophageal Disease

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT01093339

SLEEP DEPRIVATION

Details and patient eligibility

About

The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.

Full description

To determine if increased esophageal acid exposure is mediated by altering appetite regulation. To assess if there is any relationship between sleep deprivation and the serum level of TNF-alfa (a protein that can be elevated in inflammation).

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male/Female - 18-80
• 2 or more episodes of heartburn a week for last 3 months

Exclusion criteria

• Previous upper GI surgery
• Underlying co-morbidity
• Narcotic medications
• Psychotropic's and Benzodiazapines medications
• Hx of psychological abnormalities
• Hx of ETOH in previous 6 mos.
• Diabetes Mellitus
• Neuropathy
• Seizures
• Sleep Apnea
• Co-morbidity that interfere w/sleep
• Women who are pregnant, or childbearing yrs, not on BC

Trial design

50 participants in 1 patient group

No treatment

Description:

Subjects w/ condition and subjects w/o condition of GERD (gastroesophageal reflux disease)