To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days

Pfizer

Status and phase: Completed; Phase 4

Conditions: Infections, Fungal

Treatments: Drug: voriconazole

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT00300677

A1501079

Details and patient eligibility

About

To determine the amount of voriconazole in the brain after 2 loading doses and 3 maintenance doses over 3 days and compare it to the amount of voriconazole in the plasma.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects must be willing and able to provide informed consent.
• Subjects must be willing and able to be confined at the Clinical Research Unit as required by the protocol.

Exclusion criteria

• Subjects with any condition affecting drug absorption.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

voriconazole

Experimental group

Description:

voriconazole twice daily

Treatment:

Drug: voriconazole