To Develop and Validate a Nasoendoscopic Intelligent Diagnostic System for Nasopharyngeal Carcinoma

Sun Yat-sen University

Status: Enrolling

Conditions: Artificial Intelligence; Otolaryngological Disease

Treatments: Diagnostic Test: rigid nasal endoscopes

Study type: Observational

Funder types: Other

Identifiers

NCT04547673

ZSYY2020

Details and patient eligibility

About

Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province. Endoscopic examination and biopsy are the main methods used for detection and diagnosis of NPC. Early NPC patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced NPC patients.

Here, the investigators focused on the utility of artificial intelligence to detect early NPC, which based on white light imaging (WLI) and Narrow-band imaging (NBI) nasoendoscopic examination. Having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel Computer-Aided Diagnosis System.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Older than 18 years of age

Exclusion criteria

• Refuse to sign the informed consent statement
• Patients who have contraindications, e.g. coagulation dysfunction, drug allergy.

Trial design

1,000 participants in 2 patient groups

NPC group

Description:

Patients pathologically diagnosed as NPC by agreement of 2 experienced pathologists who were blinded to the corresponding endoscopic assessment.

Treatment:

Diagnostic Test: rigid nasal endoscopes

Non-NPC group

Description:

Patients pathologically diagnosed as non-NPC (including inflammatory hyperplasia, Atypical hyperplasia, Papilloma etc.) by agreement of 2 experienced pathologists who were blinded to the corresponding endoscopic assessment.

Treatment:

Diagnostic Test: rigid nasal endoscopes