To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of KP104

K

Kira Pharmacenticals

Status and phase

Enrolling
Phase 2

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Treatments

Drug: KP104

Study type

Interventional

Funder types

Industry

Identifiers

NCT05476887
KP104-201

Details and patient eligibility

About

The purpose of this study is to evaluate the safety, tolerability, immunogenicity, pharmacokinetics, pharmacodynamics, and efficacy of KP104 in complement inhibitor-naïve participants with PNH. The study will be conducted in 2 parts. Part 1 is a dose-selection study to assess escalating doses and varying dose intervals of KP104. Part 2 is a proof-of-concept (POC) study assessing the efficacy of the optimal intravenous (IV) loading dose followed by the optimal maintenance dose and regimen of KP104. Participants who complete the Initial Treatment Period and demonstrate benefit from KP104 will be eligible for a 9-month open-label extension (OLE) treatment period.

Enrollment

35 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Initial Treatment Period:

  • Documented diagnosis of PNH confirmed by flow cytometry evaluation of white blood cells and red blood cells, with granulocyte or monocyte clone size of >= 10 percent (%) within 6 months of the Screening visit.
  • Presence of 1 or more PNH-related signs or symptoms within 3 months of initiation of Screening.
  • LDH >= 2.0 × upper limit of normal (ULN) at screening.
  • Hemoglobin <= 10.0 g/dL at screening.
  • Females of childbearing potential and males must practice effective contraception from Screening until 28 days after the end of study (EOS) visit.
  • Females of childbearing potential must have a negative pregnancy test at Screening and within 24 hours prior to dosing of study drug.

Extension Treatment Period (OLE):

  • Complete the 12-week (weekly dosing) or 13-week (biweekly dosing) Initial Treatment Period per the protocol.
  • Benefited from KP104 treatment and will continue benefiting from KP104 treatment per the investigator's judgement.
  • Willing to participate in Extension Treatment Period, able to comply with this protocol and be available for the entire duration of the study.

Exclusion criteria

Initial Treatment Period:

  • Any clinically significant poorly controlled underlying illness other than PNH per discretion of investigators.
  • Treatment of any infection with IV (within 30 days of Screening) or oral (within 14 days of Screening) antibiotics, antivirals, or antifungals.
  • History of meningococcal infection.
  • History of untreated tuberculosis.
  • History of splenectomy
  • Positive serology for Hepatitis C Virus (HCV) ribonucleic acid (RNA) or human immunodeficiency virus (HIV) at Screening
  • History of bone marrow or stem cell transplantation
  • Absolute neutrophil count (ANC) <500 cells per microliter (cells/μL)
  • Reticulocyte count< 100 x 10^3 cells/μL
  • Platelet count< 30,000 cells/μL
  • History of systemic autoimmune disease
  • Estimated glomerular filtration rate (eGFR) <30 milliliters/minute/1.73 meter square (mL/min/1.73 m^2) calculated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

Extension Treatment Period (OLE):

  • Women who are pregnant.
  • Women of childbearing potential and men with sexual partners of childbearing potential who are not using adequate contraception and who are not willing to use adequate contraception.
  • Any medical condition that, in the opinion of the investigator, may pose a safety risk to a participant in this study, or may interfere with study participation.

Other protocol defined Inclusion/Exclusion criteria may apply.

Trial design

35 participants in 5 patient groups

Part 1: Dose escalation Cohort 1
Experimental group
Description:
Participants will receive escalating and varying dose intervals of KP104 every week.
Treatment:
Drug: KP104
Part 1: Dose escalation Cohort 2
Experimental group
Description:
Participants will receive escalating and varying dose intervals of KP104 weekly or biweekly.
Treatment:
Drug: KP104
Part 1: Dose escalation Cohort 3
Experimental group
Description:
Participants will receive escalating and varying dose intervals of KP104 weekly or biweekly.
Treatment:
Drug: KP104
Part 2: Proof-of-concept Cohort 1
Experimental group
Description:
Participants will receive escalating and varying dose intervals of KP104 weekly or biweekly.
Treatment:
Drug: KP104
Open-label extension (OLE)
Experimental group
Description:
Participants will receive KP104, who benefit from KP104 treatment in Part 1 and 2
Treatment:
Drug: KP104

Trial contacts and locations

0

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Central trial contact

Study Director

Data sourced from clinicaltrials.gov

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