To Exam the Effects of Phyllanthus Niruri Extracts on Human Neutrophils

Chang Gung Medical Foundation

Status: Completed

Conditions: Neutrophil; Phyllanthus Abnormis Poisoning

Treatments: Procedure: venipuncture

Study type: Observational

Funder types: Other

Identifiers

NCT05206058

202002189B0

Details and patient eligibility

About

To exam the effects of Phyllanthus niruri extracts(corilagin, phyllanthin and brevifolin) on human neutrophils

Full description

Phyllanthus niruri extracts have anti-inflammatory effects in various cellular systems (monocytes, neutrophil). However, the underlying effects and mechanisms of Phyllanthus niruri extracts on neutrophils have not yet been investigated in detail.

In this study, first we would like to systemic exam the effects of corilagin, phyllanthin and brevifolin, three major active components, on human neutrophils.

Further to clarify whether Phyllanthus niruri extracts have any effect on neutrophils that may provide some insights on the ability of these compounds to modulate the innate immune response in acute organ injury.

Enrollment: 240 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers who aged 20-35 years.
• Do not have coagulopathy, systemic infection disease and severe liver and renal function impairment
• Accept venipuncture

Exclusion criteria

• Healthy volunteers who aged over 35 years.
• Have coagulopathy, systemic infection disease and severe liver and renal function impairment