To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications

Pfizer

Status and phase: Completed; Phase 1

Conditions: Chronic Pain

Treatments: Drug: simvastatin; Drug: PF-04531083

Study type: Interventional

Funder types: Industry

Identifiers

NCT01103739

B1351007

Details and patient eligibility

About

The purpose of this study is to quantify the effect of multiple doses of PF-04531083 on the pharmacokinetics (PK) of co-administered single dose simvastatin.

Full description

observational- quantify any effects of PF_04531083 on the PK of Simvastatin

Enrollment: 24 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• young
• healthy
• male and female volunteers

Exclusion criteria

• Elderly
• Patients

Trial design

24 participants in 2 patient groups

cohort 1

Experimental group

Treatment:

Drug: simvastatin

Drug: PF-04531083

Drug: PF-04531083

Drug: simvastatin

cohort 2

Experimental group

Treatment:

Drug: simvastatin

Drug: PF-04531083

Drug: PF-04531083

Drug: simvastatin