To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery

Institute of Liver and Biliary Sciences, India

Status: Enrolling

Conditions: Liver Regeneration

Treatments: Drug: Pentoxifylline (also known as oxpentifylline); Other: Plasmalyte

Study type: Interventional

Funder types: Other

Identifiers

NCT07085806

IEC/2024/110/MA01

Details and patient eligibility

About

Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic vasculature. In a Double-blinded, randomized, controlled trial (RCT) at a single tertiary care center (2006-2009) by Petrowsky, Henrik et al (Annals of Surgery, November 2010) on 101 Non-cirrhotic patients undergoing major Hepatectomy, they demonstrated beneficial effects of Pentoxifylline on regeneration of small remnant livers (RLBW ratio ≤ 1.2%). In mice model, pentoxifylline (Tian, Yinghua, et al Proceedings of the National Academy of Sciences 103.12 (2006)) is shown to confer protective effects against small-for-size syndrome in arterialized small-for-size liver transplantation. This Randomised control trial is being conducted to analyze the effect of Pentoxifylline supplementation in live donors undergoing donor hepatectomy with respect to markers of anatomical regeneration in a high volume liver transplant center in India.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All live donors undergoing Right Donor Hepatectomy after ethical board clearance in the Department of HPB Surgery and Liver Transplantation

Exclusion criteria

• Negative consent Hypersensitivity to Pentoxifylline

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Plasmalyte

Active Comparator group

Description:

Intravenous fluid plasmalyte.

Treatment:

Other: Plasmalyte

Pentoxifylline group

Experimental group

Description:

Intravenous injection Pentoxifylline

Treatment:

Drug: Pentoxifylline (also known as oxpentifylline)