To Study the Mortality Outcome of Controlled Blood Pressure Participants (HTN-Mort)

DejthidaNathaphong

Status: Enrolling

Conditions: Hypertension (HTN); Valid MeSH Conditions

Treatments: Drug: Antihypertensive treatment

Study type: Observational

Funder types: Other

Identifiers

NCT07067632

DejthidaNathaphong

Details and patient eligibility

About

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials.

To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Full description

Sensitivity Analyses Excluding high risk of bias studies

Excluding short follow-up (<1 year)

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults ≥18 years with diagnosed hypertension

Blood pressure controlled at target values defined by the study (e.g., <140/90 mmHg or <130/80 mmHg)

Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

Exclusion criteria

• Observational or retrospective studies

Pediatric or pregnant participants

Case reports, editorials, or conference abstracts without full data

Studies not reporting mortality outcomes separately for controlled BP

Trial design

100 participants in 2 patient groups

Antihypertensive treatment

Description:

Participants assigned to interventions (pharmacological, device-based, or lifestyle) directed at lowering blood pressure or Antihypertensive agents, Blood pressure-lowering treatment, Antihypertensive therapy.

Treatment:

Drug: Antihypertensive treatment

Control/Comparator

Description:

Participants receiving placebo, standard of care, or no intervention