To Study the Effect of β-glucans on Wound Healing

National Taiwan University

Status: Completed

Conditions: Burns

Treatments: Drug: oral sugar powder; Dietary Supplement: oral beta-glucans

Study type: Interventional

Funder types: Other

Identifiers

NCT02078128

201105013MB

Details and patient eligibility

About

The purpose of this study is to determine the effect of β-glucans on wound healing.

Full description

The structure of βeta-glucan (β-glucans) is a pathogen associated molecular patterns (pathogen-associated molecular patterns, PAMPs), widely present in the cell walls of plants, bacteria, yeasts, fungi, mushrooms and algae. Modern has been reported in the literature that β-glucan can enhance the immune system of animals, and to enhance the function of the animal against bacterial, fungal and viral infections, and cancer.In this study, the use of β-glucan to enhance the biological characteristics of the non-specific immunity, to explore the impact of postoperative patients with wound healing and infection rates.The observation of the healing process to take the Leather District wounds (5 ~ 200 cm2). The experiments were carried out for 18 months, were observed record the following three: (1) the rate of wound healing, (2) The rate of infection assessment: record length of time and the point in time at all levels of antibiotic use also observe the wound change (redness, swelling, heat, pain).(3) days of hospitalization, and spend statistics. Using unpaired student's t-test analysis, group data whether the differences between groups of experimental data. represents a statistically significant when p <0.05.

Enrollment: 30 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Total burn area under 20%, two to three degree burn and need skin-grafting.
2. Subjects don't have other diseases.
3. Subjects' age between 20 to 60.

Exclusion criteria

1. Subjects with hypersensitivity.
2. Subjects with Autoimmune disease.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

oral beta-glucans

Experimental group

Description:

Daily give kg per day to 30 mg of β-glucan (30mg/kg/day), taking to the wound healed.

Treatment:

Drug: oral sugar powder

oral sugar powder

Placebo Comparator group

Description:

control group, daily give and the glucose powder 30 mg per kilogram of body weight (30mg/kg/day) a day, taking to the wound healed.

Treatment:

Dietary Supplement: oral beta-glucans