To Study the Effects of Host Genetic Factors on Liver Cirrhosis and Hepatocellular Carcinoma (HCC)
Status
Conditions
Details and patient eligibility
About
The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis and hepatocellular carcinoma. It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis and hepatocellular carcinoma.
Full description
Hepatocellular carcinoma (HCC) usually occurs in cirrhotic liver. Only 10-30% of HCC occur in non-cirrhotic liver. It has been suggested that etiological factors may differ for HCC which develop in cirrhotic liver: HCC in non-cirrhotic liver might be less often associated with viral infection and chronic alcoholism than HCC in cirrhotic livers. However, in any individual, the factors that determine HCC with or without cirrhosis remain unknown.
Cirrhosis is the end of fibrosis progression. The progress of liver fibrosis is a complex progress involving many cytokines related to activation of the hepatic stellate cells and progressive accumulation of extracellular matrix. The key enzymes responsible for deposition and degradation of all the protein component of extracellular matrix and basement membrane are matrix metalloproteinases.
To assess whether genetic variations in cytokines and matrix metalloproteinases result in diversity of liver cirrhosis and HCC, we conduct a case-control study of single nucleotide polymorphism analysis.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Clinical diagnosis of hepatocellular carcinoma
- restrict the casual agent of liver disease to viral infection
Exclusion criteria
- the casual aget of liver disease is not viral infection, such as alcohol abuse
Trial design
320 participants in 2 patient groups
Trial contacts and locations
Loading...
Central trial contact
Tzu-Min Hung, M.S.
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal