Tobacco Approach Avoidance Training for Adolescent Smokers-2 (AAT-2)

Yale University

Status and phase: Completed; Phase 2

Conditions: Tobacco Use Disorder

Treatments: Behavioral: AAT-experiment; Behavioral: AAT-placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01625637

1103008127-2

Details and patient eligibility

About

This is a two part study. In Study 2, smokers who want to quit smoking will participate in a 4 week smoking cessation program combining weekly cognitive behavioral therapy (CBT) with weekly regular-AAT or placebo-AAT training. We hypothesize that adolescent smokers will exhibit stronger approach tendencies towards smoking-related stimuli in the tobacco Approach Avoidance Training (AAT) task when compared with nonsmokers and that adolescent smokers who are trained to avoid smoking related stimuli using the AAT will avoid tobacco approach tendencies in the AAT test trials and the Implicit Association Task, when compared to adolescent smokers who are not exposed to AAT training. We also hypothesize that adolescent smokers who are trained to avoid tobacco in a training AAT in combination with CBT will have better abstinence rates compared to those who receive placebo AAT training with CBT.

Enrollment: 66 patients

Sex: All

Ages: 13 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Inclusion Criteria:
• Between ages 13-18 years
• Able to read and write in English.
• Smokers: Smoking 5 or more cigarettes daily for at least 6 months; Baseline urine cotinine levels > 500 ng/ml
• Nonsmokers: Never smokers; Baseline urine cotinine levels < 50 ng/ml

Exclusion criteria

• Current criteria for dependence on another psychoactive substance
• Current diagnosis of psychosis, major depression or panic disorder
• Regular use of any psychoactive drugs including anxiolytics and antidepressants unless the medication has been taken consistently for 2 months, is currently being monitored by a physician, and the condition for which the medication is taken is considered to be stable
• Pregnant or lactating girls, based on self report.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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66 participants in 2 patient groups, including a placebo group

AAT-avoid cigarette condition

Experimental group

Description:

Adolescent smokers are trained to avoid tobacco in a training AAT

Treatment:

Behavioral: AAT-experiment

AAT-no contingency continued assessment

Placebo Comparator group

Treatment:

Behavioral: AAT-placebo