Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Stanford University

Status

Completed

Conditions

Alopecia Totalis

Alopecia Universalis

Alopecia Areata

Treatments

Drug: Tofacitinib

Study type

Interventional

Funder types

Other

Identifiers

NCT02312882

IRB-31790 (Other Identifier)

31790ORO

Details and patient eligibility

About

The purpose of this study is to investigate the ability of tofacitinib citrate, a Janus kinase inhibitor, to generate hair regrowth in patients with moderate to severe alopecia areata and its variants.

Full description

This study is an open-label pilot study. Participants will be treated with oral tofacitinib for 3 months.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age >= 18 years old
Diagnosis of alopecia areata with >50% scalp involvement, alopecia totalis, or alopecia universalis
Hair loss present for at least 6 months
No treatment for alopecia areata in past 2 months
No evidence of hair regrowth
Females of childbearing potential must use birth control while taking the medication and there must be a negative pregnancy test documented prior to starting the medication
Fluent in spoken and written English

Exclusion criteria

Age <18 years old
Patients have received treatment known to affect alopecia areata within 2 months of enrolling in the study
Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin)
Patients known to be HIV or hepatitis B or C positive
Patients with positive tuberculin skin test or positive QuantiFERON TB test
Patients with leukopenia or anemia
Patients with renal or hepatic impairment
Patients with peptic ulcer disease
Patients taking immunosuppressive medications, including but not limited to prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or TNH-alpha inhibitors
Women of childbearing potential who are unable or unwilling to use birth control while taking the medication
Women who are pregnant or nursing