Tolerance and Utilization of Agave Inulin in Healthy Adults

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Tolerance

Treatments: Other: Placebo; Other: Agave Inulin

Study type: Interventional

Funder types: Other

Identifiers

NCT01925560

13359 (Other Grant/Funding Number)

Details and patient eligibility

About

The objective of this study is to assess the tolerance and utilization of agave inulin. This will be accomplished through analyses of breath and fecal samples to quantify fermentation end-products- hydrogen, carbon dioxide, and methane will be measured in the breath, and short-chain fatty acids, ammonia, phenol, and indole will be measured in feces. Microbial populations will also be measured in fecal samples.

Full description

The objective of this study is to assess the tolerance and utilization of agave inulin. This will be accomplished through analyses of breath and fecal samples to quantify fermentation end-products- hydrogen, carbon dioxide, and methane will be measured in the breath, and short-chain fatty acids, ammonia, phenol, and indole will be measured in feces. Microbial populations will also be measured in fecal samples.

Enrollment: 30 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• have body mass index (BMI) between 18.5 and 29.5 kg/m2
• free of metabolic and gastrointestinal diseases

Exclusion criteria

• BMI less than 18.5 or greater than 29.5 kg/m2
• presence of metabolic and gastrointestinal diseases
• pregnant or lactating
• taking medications that impact bowel function

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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30 participants in 3 patient groups

Group A- agave inulin or placebo

Experimental group

Description:

Participant in this group will receive Agave Inulin dose of 5 or 7.5 grams per day or placebo.

Treatment:

Other: Placebo

Other: Agave Inulin

Group B- agave inulin or placebo

Experimental group

Description:

Participants in this group will receive Agave Inulin dose of 5 or 7.5 grams per day or placebo

Treatment:

Other: Placebo

Other: Agave Inulin

Group C-agave inulin or placebo

Experimental group

Description:

Participants in this group will receive Agave Inulin dose of 5 or 7.5 grams per day or placebo

Treatment:

Other: Placebo

Other: Agave Inulin