Tolerance and Utilization of Polydextrose, Inulin, and Soluble Corn Fiber

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Tolerance

Treatments: Other: soluble corn fiber; Other: polydextrose

Study type: Interventional

Funder types: Other

Identifiers

NCT02091349

09491

Details and patient eligibility

About

The objective of this study is to determine the tolerance and utilization of polydextrose and soluble corn fiber through analyses of fecal samples of fermentative end-products (short-chain fatty acids, ammonia, phenol, and indole) and shifts in microbial populations.

Full description

Soluble fibers have been shown to have many positive effects in humans, including laxation and maintaining gastrointestinal health. It is expected that feeding soluble fibers will decrease protein fermentative end=products while increasing carbohydrate fermenative end-products, and lead to a more beneficial microbial profile. Determination of the effects of nutriose and polydextrose when included as supplemental fiber in a human diet will give insights to its potential to maintain or improve gut health and highlight its use in the food industry.

The object of this study are first to determine the tolerance of soluble fibers polydextrose, inulin and nutriose when provided as supplemental fiber to an existing diet. The second objective is to determine the utilization of polydextrose and nutriose through analyses of fecal samples of fermentative end-products and shifts in microbial populations.

Enrollment: 25 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• have body mass index (BMI) between 18.5 and 31 kg/m2
• free of metabolic and gastrointestinal disease

Exclusion criteria

• BMI less than 18.5 or greater than 31 kg/m2
• presence of metabolic or gastrointestinal diseases

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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25 participants in 3 patient groups, including a placebo group

Group A- placebo

Placebo Comparator group

Description:

control- snack bar or muffin containing no fiber

Treatment:

Other: soluble corn fiber

Other: polydextrose

Group B- polydextrose

Experimental group

Description:

polydextrose- randomly bonded polysaccharide of glucose which is poorly digested in small intestine

Treatment:

Other: soluble corn fiber

Other: polydextrose

Group C- soluble corn fiber

Experimental group

Description:

Soluble corn fiber made from corn starch and contains oligosaccharides with random glyucosyl bonds and may contain minor amounts of monosaccharides

Treatment:

Other: soluble corn fiber

Other: polydextrose