Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure

University of Chile

Status: Completed

Conditions: Tolerance; Anesthesia

Treatments: Drug: Sevoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT04188782

0362019

Details and patient eligibility

About

Deep sedation or general anesthesia is frequently required for infant that need radiotherapy to treat malignancies. As radiation therapy usually consist of several sessions, these patients are exposure to several consecutive anesthetic exposures (e.g. for some central nervous system tumors 30 sessions of radiotherapy are required). In our center, this 30-min anesthetic exposure are with sevoflurane. Considering that repeated daily exposure to such potent drugs, as general anesthetics, may induce tolerance, it is reasonable to explore whether this phenomenon is occurring in this population.

The aim of this observational study was to determine if a repeated exposure to sevoflurane is associated with the development of clinical and electroencephalographic tolerance.

We will enroll 16 pediatric patients, and we will measure the time needed to appropriately place the laryngeal mask (clinical effect) and we also will compare the electroencephalographic signal under anesthesia across the different sessions (electroencephalographic effect).

Full description

The purpose of this study is to evaluate the development of tolerance to sevoflurane in children undergoing repeated drug exposure.

We will evaluate the development of tolerance in two ways:

Clinical: as the time needed to perform the inhalation induction, with a standardized protocol.

Electroencephalographic: we will record every 3 sessions the electroencephalographic activity of the patients. We will perform classical spectral analysis, and coherence analysis as well.

This observational study will be mainly exploratory since there are no other previous report in this topic

Enrollment: 24 patients

Sex: All

Ages: 10 months to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing radiotherapy
• Requiring general anesthesia

Exclusion criteria

• Previous Radiotherapy
• Malignant Hyperthermia history

Trial design

24 participants in 1 patient group

Pediatric patients undergoing radiotherapy

Description:

Pediatric patients undergoing general anesthesia for radiotherapy treatment. General anesthesia will be accomplished exclusively by the administration of sevoflurane. The inhalatory induction will be performed with sevofluorane at 8% with O2 4Lt/min. The maintenance will be with sevofluorane at an end tidal of 2.5% with 1Lt/min of O2. The EEG will be obtain with SedLine monitor

Treatment:

Drug: Sevoflurane