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About
The purpose of this study is to evaluate the effect of a high zone tolerizing regimen of pegloticase on clinical outcome, as defined by an serum uric acid level <6 mg/dL, in patients with chronic, refractory gout.
Full description
This is an exploratory open-label, multicenter study to evaluate the effectiveness of a 16-week high zone tolerance regimen of pegloticase on response to therapy (serum uric acid <6 mg/dL) with this drug in adult hyperuricemic patients with gout refractory to conventional therapy.
Eligible subjects will receive 1 of 3 different loading doses (8, 12, and 16 mg) on Study Day 1, and then receive 8 mg on Week 2 and 3, followed by 8 mg every 2 weeks through Week 17 for a total of 10 doses.
Subjects will be monitored for efficacy and safety endpoints through Week 17. Subjects will also have blood drawn for pegloticase levels prior to each dose on Weeks 2, 3, 5, 7, 9, 11, 13,15, and 17. Following Study Week 17, subjects will have an option to continue dosing for an additional 8 weeks.
A subset of subjects will participate in additional pharmacokinetic (PK) assessments.
The study duration, per enrolled patient, will be approximately 26 weeks including a 2-week screening period, a 16-week treatment period (end of treatment [EOT] visit Week 17), and an optional 8-week dosing extension.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Glucose-6-phosphate dehydrogenase (G6PD) deficiency (confirmed at Screening visit)
Non-compensated congestive heart failure, uncontrolled arrhythmia, treatment for acute coronary syndrome (ACS) (myocardial infarction or unstable angina) or hospitalization for congestive heart failure within 3 months of screening or uncontrolled blood pressure (>160/100 mm Hg) at baseline (Screening and pre-dose at Week 1 visit )
Women of childbearing potential defined as:
Prior treatment with pegloticase or another recombinant uricase
Prior treatment or concomitant therapy with a polyethylene glycol (PEG) conjugated drug
Known allergy to PEG products or history of anaphylactic reaction to a recombinant protein or porcine product
Concurrent treatment with urate lowering agents (ULAs), such as allopurinol and febuxostat. Patients treated with these medications must discontinue treatment 7 days prior to the first dose of study drug
Recipient of an investigational drug within 4 weeks prior to study drug administration or plans to take an investigational agent during the study
Current liver disease as determined by alanine transaminase (ALT) or aspartate transaminase (AST) levels >3 times upper limit of normal (ULN)
History of malignancy within 5 years other than basal cell skin cancer or carcinoma in situ of the cervix
Has any other medical or psychological condition which, in the opinion of the Investigator, might create undue risk to the patient or interfere with the patient's ability to comply with the protocol requirements, or to complete the study
Solid organ transplant recipients
Uncontrolled hyperglycemia with a plasma glucose value >240 mg/dL at screening
Currently on dialysis
Additional Exclusion Criteria for Imaging Sub-study Only
Contraindication to receiving a gadolinium-based contrast agent (GBCA) or > 2 previous lifetime exposures to a GBCA
Implanted pacemaker, certain older intracranial aneurysm clips, cochlear implants, certain prosthetic devices, implanted drug infusion pumps, neurostimulators, bone-growth stimulators, certain intrauterine contraceptive devices, or any other type of iron-based metal implants.
Any internal metallic objects such as bullets or shrapnel, as well as most surgical clips, pins, plates, screws, metal sutures, or wire mesh.
Additional Exclusion Criteria for FDG-PET-CT Sub-study Only
Contraindication to FDG
Additional Exclusion Criteria for Pegloticase and AZA Therapy Arm Only
Any active serious bacterial infection (2 weeks prior to screening) requiring antibiotic treatment
Severe chronic or recurrent bacterial infections, such as recurrent pneumonia, chronic bronchiectasis
Current immunocompromised condition, including current or chronic treatment with systemic immunosuppressive agents (e.g., prednisone or equivalent dose >510 mg/day)
At risk for tuberculosis. Specifically, subjects with: a) current clinical, radiographic, or laboratory evidence of active or latent tuberculosis; b) a history of active tuberculosis within the last 31 years even if it was treated; c) a history of active tuberculosis >31 years ago unless there is documentation that the prior anti-tuberculosis treatment was appropriate in duration and type
Known history of hepatitis B surface antigen-positivity or hepatitis B DNA positivity
Known history of hepatitis C RNA-positivity
Known history of human immunodeficiency virus positivity
Severe chronic renal impairment (glomerular filtration rate <25 mL/min/1.73 m2)
AZA treatment is contraindicated or considered inappropriate
Subject has a homozygous or heterozygous thiopurine methyltransferase (TPMT) variant genotype
Diagnosis of osteomyelitis
Known hypoxanthine-guanine phosphoribosyl-transferase deficiency, such as Lesch-Nyhan and Kelley-Seegmiller syndrome
Concurrent use of a xanthine oxidase inhibitor
Primary purpose
Allocation
Interventional model
Masking
132 participants in 6 patient groups
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Data sourced from clinicaltrials.gov
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